home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9603.zip
/
M9630249.TXT
< prev
next >
Wrap
Text File
|
1996-02-27
|
2KB
|
40 lines
Document 0249
DOCN M9630249
TI Disseminated acanthamebiasis in patients with AIDS. A report of five
cases and a review of the literature.
DT 9603
AU Murakawa GJ; McCalmont T; Altman J; Telang GH; Hoffman MD; Kantor GR;
Berger TG; Department of Dermatology, University of California at San;
Francisco, USA.
SO Arch Dermatol. 1995 Nov;131(11):1291-6. Unique Identifier : AIDSLINE
MED/96067816
AB BACKGROUND: Acanthamoeba and Leptomyxida are free-living amebae that
cause granulomatous amebic encephalitis, a rare, slowly progressive,
fatal neurologic process seen in immunosuppressed hosts. In addition,
these organisms produce disseminated cutaneous lesions and involve other
organs, particularly in patients with the acquired immunodeficiency
syndrome (AIDS). RESULTS: We report five cases of disseminated
acanthamebiasis in patients with AIDS, each with cutaneous
manifestations but lacking central nervous system involvement. The
medial CD4+ T-cell count was 0.024 x 10(9)/L. Skin lesions included
pustules, subcutaneous and deep dermal nodules, and ulcers, most often
seen on the extremities and face. Histopathologically, both pustular and
vasculitic changes were observed; in all cases, the microscopic
identification of organisms was difficult because of the macrophagelike
appearance of the microbes in routine sections. CONCLUSIONS: Skin
lesions are the most common reported presentation of infections caused
by Acanthamoeba and Leptomyxida organisms in patients with AIDS, a
minority of whom have central nervous system manifestations. A high
index of suspicion is necessary for both the dermatologist and the
dermatopathologist. Prognosis is guarded, but early treatment using a
combination of intravenous pentamidine and oral fluconazole,
sulfadiazine, and flucytosine may be beneficial.
DE *Acanthamoeba Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult
Amebiasis/*COMPLICATIONS/PATHOLOGY Animal Case Report Human Male
Middle Age Skin Diseases, Parasitic/*COMPLICATIONS/PATHOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).